Ny publikation av Stephanie Paillard-Borg
En artikel har publicerats av Stéphanie Paillard-Borg and medarbetarna i tidskriften Endocrine
The prevalence and determinants of hypothyroidism in hospitalized patients with type 2 diabetes mellitus
Objectives：The purpose of this study was to investigate the prevalence of hypothyroidism among hospitalized patients with type 2 diabetes mellitus (T2DM) and its related factors, and to assess the prevalence of macrovascular and microvascular diseases among T2DM inpatients with hypothyroidism and euthyroidism.
Methods: A total of 1662 T2DM inpatients hospitalized at the Metabolic Diseases Hospital, Tianjin Medical University from January 1, 2008 to March 1, 2013 were included in this study. Information on demographic and anthropometric factors and additional variables related to hypothyroidism were collected from medical records. Prevalence rates were calculated and standardized using direct method based on the age- and sex-specific structure of all participants. Data were analyzed using binary logistic regression with adjustment for potential confounders. Results: The prevalence of hypothyroidism among T2DM inpatients was 6.8%, and 77.0% of the patients with hypothyroidism had subclinical hypothyroidism. The prevalence of hypothyroidism increased with age, and was higher in women (10.8%) than in men (3.4%). Older age (OR, 1.70; 95% CI, 1.04 to 2.60), female gender (OR, 1.92; 95% CI, 1.04 to 3.54) and positive TPO-Ab (OR, 4.50; 95% CI, 2.63 to 7.72) were associated with higher odds of hypothyroidism among T2DM inpatients. The T2DM inpatients with hypothyroidism had higher prevalence of cerebrovascular diseases than those with euthyroidism after adjustment for age and gender.
Conclusions: The prevalence of hypothyroidism among T2DM inpatients was 6.8%, and most patients (77%) had subclinical hypothyroidism. Older age, female gender and positive TPO-Ab could be indicators for detecting hypothyroidism in T2DM inpatients.